Expertise in the Physical Characterisation of Materials
01763 262333
MCA Services Unit 1A Long Barn, North End, Meldreth, Cambridgeshire SG8 6NT UK
01763 262333
© MCA Services
Key Benefits:· Formation of critical parameters to the QbD framework All analyses in accordance with ISO 17025:2005 Assessment of raw materials Assessment of batch-to-batch variability Investigations of batch failures Investigation of long term stability & shelf life Investigation of counterfeit materials Analysis of most sample types: powders, granules & most tablets forms Analysis according to existing methods Active assistance with interpretation of results and data presentation Key Techniques BET Surface Area - including krypton adsorption for low area materials Mercury Porosimetry - pore size, volume and area distribution Mercury Porosimetry - volume porosity and permeability measurement Gas Adsorption - pore size, volume and area distribution Micropore Analysis - pore size, volume and area  distribution Density measurement - absolute density & bulk density
Tablet dissolution rate related to porosity by mercury porosimetry The porosity characteristics of the API, excipients, powder blend and finished tablet, caplet or granule mixture have direct links to performance characteristics such as dissolution rate, solubility, tablet strength and long term stability / shelf life. Control over porosity characteristics is essential for batch-to-batch uniformity and analysis of these characteristics has proven to be a valuable tool in the investigation of critical performance parameters within a QbD framework, batch failures and counterfeit drugs.  MCA Services offers a complete suite of techniques for the characterisation of material porosity with the experience and expertise to actively assist with interpretation of results  and relating these to development criteria and performance characteristics. Our ongoing in-house research continues to highlight applications to the pharmaceutical sector.
PHARMACEUTICAL ANALYSIS AT MCA SERVICES Knowledge and control of the physical properties of pharmaceutical materials is critical throughout product development and formulation, testing, scale-up and the ultimate manufacturing process. All of our analyses are conducted in accordance with ISO17025:2005 requirements. Characteristics of pore size distribution, pore volume and density often have profound effects on the performance of a solid dosage form and in turn, this is influenced but the porous characteristics of constituent powders and granules.  Pore size and volume is often independent of other commonly investigated parameters: such as particle size distribution and specific surface area.
LATEST RESEARCH NEWS: New research paper by MCA Services in International Journal of Pharmaceutics, 530 (2017) 364-376: Gas adsorption on commercial magnesium stearate: Effects of degassing conditions on nitrogen BET surface area and isotherm characteristics    View Journal Article 
Expertise in the Physical Characterisation of Materials
MCA Services Unit 1A Long Barn, North End, Meldreth, Cambridgeshire SG8 6NT UK
01763 262333
© MCA Services
Key Benefits:· Formation of critical parameters to the QbD framework All analyses in accordance with ISO17025:2005 Assessment of raw materials Assessment of batch-to-batch variability Investigations of batch failures Investigation of long term stability & shelf life Investigation of counterfeit materials Analysis of most sample types: powders, granules & most tablets forms Analysis according to existing methods Active assistance with interpretation of results and data presentation Key Techniques BET Surface Area - including krypton adsorption for low area materials Mercury Porosimetry - pore size, volume and area distribution Mercury Porosimetry - volume porosity and permeability measurement Gas Adsorption - pore size, volume and area distribution Micropore Analysis - pore size, volume and area  distribution Density measurement - absolute density & bulk density
Tablet dissolution rate related to porosity by mercury porosimetry
The porosity characteristics of the API, excipients, powder blend and finished tablet, caplet or granule mixture have direct links to performance characteristics such as dissolution rate, solubility, tablet strength and long term stability / shelf life. Control over porosity characteristics is essential for batch-to-batch uniformity and analysis of these characteristics has proven to be a valuable tool in the investigation of critical performance parameters within a QbD framework, batch failures and counterfeit drugs. MCA Services offers a complete suite of techniques for the characterisation of material porosity with the experience and expertise to actively assist with interpretation of results  and relating these to development criteria and performance characteristics. Our ongoing in-house research continues to highlight applications to the pharmaceutical sector.
PHARMACEUTICAL ANALYSIS Knowledge and control of the physical properties of pharmaceutical materials is critical throughout product development and formulation, testing, scale-up and the ultimate manufacturing process. Characteristics of pore size distribution, pore volume and density often have profound effects on the performance of a solid dosage form and in turn, this is influenced but the porous characteristics of constituent powders and granules.  Pore size and volume is often independent of other commonly investigated parameters: such as particle size distribution and specific surface area.
01763262333
LATEST RESEARCH NEWS: New research paper by MCA Services in International Journal of Pharmaceutics Gas adsorption on commercial magnesium stearate: Effects of degassing conditions on nitrogen BET surface area and isotherm characteristics    View Journal Article